LaBue, of counsel; Ms. Fruchtman and Joseph G. Buro, on the brief. Debra W. Silkowitz, Assistant Attorney General, of counsel; Ms. Levine, on the brief. Petitioner Thomas J. Kim, M. The reprimand resulted from a prior interaction between appellant and a patient, which took place in California and had not been determined to be misconduct how to stop false cps reports our sister state.

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We conclude the Board's actions are within its statutory authority, and we affirm. Appellant is a board certified obstetrician and gynecologist, nationally-recognized for stipanie a palenie jazyka work in reproductive endocrinology and infertility. Appellant, who was a licensed physician in California, moved to New Jersey on May 3,and submitted a license application to the Board.

In his application, appellant disclosed he had settled a malpractice action filed by a former client, J. Appellant was requested to appear before the Board's Credentials Committee Committee to discuss this issue and his prior employment. Appellant responded to the Board's inquiry.

He revealed J. Appellant and J. The two became intimate and J. Thereafter, appellant ended the affair. Also, J. The matter was settled with no admission of wrongdoing at approximately the same time appellant moved to New Jersey.Don't have a profile? Get the performance and accuracy you need with solvents that minimize the risk of contaminants and maximize instrument sensitivity and detection power. View Solvents. The J. View Acids. Meet the most demanding research and analytical testing applications, such as proteomics, drug discovery and more, with J.

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To identify other potential mechanisms that contribute to disease progression, we used array-based comparative genomic hybridization aCGH to compare genomic profiles of EGFR mutant tumors from untreated patients with those from patients with acquired resistance.

Among three loci demonstrating recurrent copy number alterations CNAs specific to the acquired resistance set, one contained the MET proto-oncogene. Growth inhibition studies demonstrate that these cells are resistant to both erlotinib and an irreversible EGFR inhibitor CL, but sensitive to a multikinase inhibitor XL with potent activity against MET.

Taken together, these data suggest that MET amplification occurs independently of EGFR TM mutations and that MET may be a clinically relevant therapeutic target for some patients with acquired resistance to gefitinib or erlotinib.

Somatic mutations in exons encoding the tyrosine kinase domain of the epidermal growth factor receptor EGFR are found in a proportion of lung adenocarcinomas 1. Both genetic lesions are associated with increased sensitivity of lung adenocarcinomas to the selective EGFR kinase inhibitors, gefitinib Iressa and erlotinib Tarceva 2 — 4.

Unfortunately, lung cancers with drug-sensitive EGFR mutations that initially respond to gefitinib or erlotinib eventually develop acquired resistance 67. In approximately half of cases, tumor cells obtained after disease progression contain a second-site mutation in the EGFR kinase domain 8 — Other mechanisms that contribute to resistance to EGFR inhibitors, either in the absence or presence of the TM mutation, remain to be established. We compared these results with those obtained from genomic analysis of lung adenocarcinomas with EGFR mutations resected from 38 patients who were never treated with kinase inhibitors.

Among three genomic loci with recurrent differences in CNAs between the two groups, we focused on one that encompasses the gene encoding the MET tyrosine kinase.

Using several molecular and cellular techniques, we verified the aCGH findings and then extended our studies to additional EGFR mutant tumors. We obtained 12 tumor DNA samples from 12 patients with lung adenocarcinomas containing EGFR mutations and documented disease progression after prolonged treatment on gefitinib or erlotinib. We analyzed fluorescence ratios of scanned images of the arrays to identify statistically significant changes in copy number using a version of the circular binary segmentation algorithm The overall pattern of large-scale genomic events was consistent with previous high-resolution genomic profiles of human lung cancer 1415 Fig.

Shown is the percentage of samples with CNAs after data segmentation y axis plotted for each probe evenly aligned along the x axis in chromosome order. Asterisks denote amplifications that occurred in more than one sample in the acquired resistance cohort.

We next compared results from tumors with acquired resistance to those obtained from a separate aCGH analysis of 38 mutant EGFR lung adenocarcinomas resected from patients who had never received treatment with kinase inhibitors. DNA from the untreated tumors was analyzed by using 44K Agilent chips The recurrent genomic gains and losses in these samples appeared grossly similar to the acquired resistance set Fig.

After mode-centering, comparison of the two sets at the location of each of the 44K probes; see Materials and Methods revealed three major loci of recurrent CNAs unique to samples from patients with acquired resistance Fig.

One locus, at 7p, includes EGFR and was amplified compared with the untreated set in 3 of the 12 tumor samples nos. These results are consistent with the notion that EGFR mutation and amplification occur frequently in tumors from patients with acquired resistance A second locus, at an interval encompassing 7q The gene encoding MET lies in this interval and encodes a receptor tyrosine kinase implicated in the development, maintenance, and progression of cancers in both animals and humans reviewed in ref.

The third CNA occurred on 5p We did not observe any genomic deletions that were significantly overrepresented in either treated or untreated groups. Genomic loci with significant copy number changes in 12 EGFR mutant tumor samples from patients with acquired resistance compared with 38 EGFR mutant tumor samples from untreated patients. We next examined the individual aCGH profiles of the region of interest on chromosome 7 at higher resolution in all of the samples.

Eleven of the samples showed broad gains of chromosome 7, including the region of EGFR data not shown.Now we deal with the case where the mass of an object is changing. We analyze the motion of a rocket, which changes its velocity and hence its momentum by ejecting burned fuel gases, thus causing it to accelerate in the opposite direction of the velocity of the ejected fuel see Figure.

If the burn rate of the fuel is constant, and the velocity at which the exhaust is ejected is also constant, what is the change of velocity of the rocket as a result of burning all of its fuel? Figure 9. Solid fuel boosters on either side were recovered and refueled after each flight, and the entire orbiter returned to Earth for use in subsequent flights. The large liquid fuel tank was expended. The space shuttle was a complex assemblage of technologies, employing both solid and liquid fuel, and pioneering ceramic tiles as reentry heat shields.

As a result, it permitted multiple launches as opposed to single-use rockets. The problem has the mass and velocity of the rocket changing; also, the total mass of ejected gases is changing. Thus, we can apply conservation of momentum to answer the question Figure.

Conservation of momentum enables us to determine the resulting change of velocity. The mass m is the instantaneous total mass of the rocket i. At the same moment that the total instantaneous rocket mass is m i. Thus, the initial momentum of the system is.

Therefore, including both the change for the rocket and the change for the exhaust gas, the final momentum of the system is. Since all vectors are in the x -direction, we drop the vector notation. Applying conservation of momentum, we obtain. We neglect this term, therefore, and obtain:. Integrating from the initial mass m i to the final mass m of the rocket gives us the result we are after:. This result is called the rocket equation.

It was originally derived by the Soviet physicist Konstantin Tsiolkovsky in In rocket problems, the most common questions are finding the change of velocity due to burning some amount of fuel for some amount of time; or to determine the acceleration that results from burning fuel. A spacecraft is moving in gravity-free space along a straight path when its pilot decides to accelerate forward. He turns on the thrusters, and burned fuel is ejected at a constant rate of [latex] 2.

The initial mass of the spacecraft and its unburned fuel is [latex] 2. Substituting, we get. Notice that, as expected, the acceleration is a function of time. Substituting the given numbers:. Acceleration is increasing, as we expected. Significance Notice that the acceleration is not constant; as a result, any dynamical quantities must be calculated either using integrals, or more easily conservation of total energy.

Differentiation with respect to time gives. Thus, time rate of change of the mass of the rocket is the same as that of the fuel.

n. ?, 1- del z~/oq i to.j?

This gives us. However, in the presence of gravity, it matters a lot. When that is the case, the gas velocity and gas momentum are in the same direction as that of the rocket. How is the rocket still able to obtain thrust by ejecting the gases? Yes, the rocket speed can exceed the exhaust speed of the gases it ejects.

n. ?, 1- del z~/oq i to.j?

The thrust of the rocket does not depend on the relative speeds of the gases and rocket, it simply depends on conservation of momentum.In mathematics and signal processingthe Z-transform converts a discrete-time signalwhich is a sequence of real or complex numbersinto a complex frequency-domain representation.

It can be considered as a discrete-time equivalent of the Laplace transform. This similarity is explored in the theory of time-scale calculus.

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The basic idea now known as the Z-transform was known to Laplaceand it was re-introduced in by W. Hurewicz [1] [2] and others as a way to treat sampled-data control systems used with radar. It gives a tractable way to solve linear, constant-coefficient difference equations. It was later dubbed "the z-transform" by Ragazzini and Zadeh in the sampled-data control group at Columbia University in The modified or advanced Z-transform was later developed and popularized by E.

The idea contained within the Z-transform is also known in mathematical literature as the method of generating functions which can be traced back as early as when it was introduced by de Moivre in conjunction with probability theory. The Z-transform can be defined as either a one-sided or two-sided transform. In signal processingthis definition can be used to evaluate the Z-transform of the unit impulse response of a discrete-time causal system.

The properties of Z-transforms below have useful interpretations in the context of probability theory. A special case of this contour integral occurs when C is the unit circle. With this contour, the inverse Z-transform simplifies to the inverse discrete-time Fourier transformor Fourier seriesof the periodic values of the Z-transform around the unit circle:.

The Z-transform with a finite range of n and a finite number of uniformly spaced z values can be computed efficiently via Bluestein's FFT algorithm. The discrete-time Fourier transform DTFT —not to be confused with the discrete Fourier transform DFT —is a special case of such a Z-transform obtained by restricting z to lie on the unit circle.

The region of convergence ROC is the set of points in the complex plane for which the Z-transform summation converges. The last equality arises from the infinite geometric series and the equality only holds if 0. In this case the ROC is the complex plane with a disc of radius 0. Using the infinite geometric seriesagain, the equality only holds if 0.

In this case the ROC is a disc centered at the origin and of radius 0. What differentiates this example from the previous example is only the ROC. This is intentional to demonstrate that the transform result alone is insufficient.

Creating the pole—zero plot for the causal and anticausal case show that the ROC for either case does not include the pole that is at 0. This extends to cases with multiple poles: the ROC will never contain poles. The ROC creates a circular band.

For example. The ROC will be 0. Such a system is called a mixed-causality system as it contains a causal term 0. The stability of a system can also be determined by knowing the ROC alone. If the ROC contains the unit circle i. Let us assume we are provided a Z-transform of a system without a ROC i. We can determine a unique x[n] provided we desire the following:. For stability the ROC must contain the unit circle.

If we need a causal system then the ROC must contain infinity and the system function will be a right-sided sequence.Sign in. Where to pay. Chase Pay online. Chase Pay app. Great news. Chase for Business. Personal Banking. Commercial Banking. Customer Service. Give Feedback. This video uses illustrated animation and infographics, including a graphic of a mobile device that displays screens from the Chase Pay Mobile App.

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